Comparing the pre-pandemic with the COVID-19 positive cohort, differences were found for mitral valve disease, congestive heart failure, COPD, history of myocardial infarction, obesity, diabetes mellitus, hypertension, peripheral vascular disease, hyperlipidemia, smoking, and history of AF/AFl (see Table 1). The COVID-19 positive patients had a higher proportion of Blacks (776 out of 4838 16%), Hispanics (243 out of 4838 5%) and others (859 out of 4838 17.8%) with a smaller proportion of Whites (2737 out of 4838 56.6%), while both COVID-19 negative and pre-pandemic patients showed a higher proportion of Whites (37,147 out of 47,519 and 21,142 out of 26,368 respectively).Īmong the known risk factors for AF, we found differences between the unmatched COVID-19 positive and negative cohorts regarding preexisting chronic renal failure, mitral valve disease, obesity, diabetes mellitus, hypertension, peripheral vascular disease, hyperlipidemia, smoking, and history of paroxysmal AF/AFl. In this retrospective cohort study we hypothesized that COVID-19 positive patients hospitalized between and would have a greater odds of in-hospital AF compared to COVID-19 negative patients hospitalized during the same time period as well as pre-pandemic historical controls.īoth groups of comparisons showed differences in the proportion of racial groups ( P < 0.001 standardized differences 0.492 and 0.533 respectively). The link of COVID-19 and AF needs to be verified. mesenteric ischemia, myocardial infarction). In AF the risk for complications is elevated-the odds for an ischemic stroke is increased by fivefold 6, with further thromboembolic events possible (e.g. The most common cardiac arrhythmia is atrial fibrillation (AF) with myocardial inflammation increasing the risk for the development of AF 5. Arrhythmias have previously been reported in infections with COVID-19 4. In general, cardiac disease is often accompanied by heart rhythm disorders, which increase the likelihood for further complications. Stressing its clinical impact, cardiac MRI showed signs of myocarditis even in previously asymptomatic athletes who were infected 3. Molecularly, direct cellular damage is caused to sarcomere structures 2. Specifically, evidence point towards myocardial involvement 1. Additional effects of the virus on other organ systems have been reported. Patients suffering from COVID-19 predominately exhibit pulmonary symptoms. Adequate detection and treatment of AF is essential to reduce the burden of disease. ![]() While COVID-19 continues to affect many people around the world, AF may be a significant cause for morbidity and mortality. Our study demonstrated an increased risk for AF, directing the attention for improved screening and treatment regimens for the sequelae of COVID-19. After adjusting for demographics and comorbidities, COVID-19 positive patients had 1.19 times the odds (95% CI 1.00, 1.41) of developing AF compared to COVID-19 negative patients and 1.57 times the odds (95% CI 1.23, 2.00) of developing AF compared to pre-pandemic patients. ![]() Of 78,725 patients eligible for analysis, 11,004 COVID-19 negative patients were matched to 3,090 COVID-19 positive patients and 5005 pre-pandemic patients were matched to 2283 COVID-19 positive patients. We matched on common risk factors for AF and then used multivariable logistic regression to estimate the odds for AF or AFl. All patients ≥ 18 years who were hospitalized and received a PCR test for SARS-CoV-2 were screened for inclusion as well as patients from a pre-pandemic cohort. This retrospective study used electronic medical records to detect patients with COVID-19 and their comorbidities within the Mass General Brigham hospital system. The objective of our study was to investigate the association of COVID-19 and atrial fibrillation (AF) or atrial flutter (AFl) in hospitalized patients. ![]() Myocardial involvement has been described for infections with SARS-CoV-2 which may lead to an increase in morbidity and mortality. COVID-19 is associated with significant extrapulmonary symptoms.
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